ea0013oc11 | Clinical and translational endocrinology | SFEBES2007
Hammer Fabian
, Bozhinova Nadya
, Hughes Beverly A
, Fassnacht Martin
, Stewart Paul M
, Allolio Bruno
, Arlt Wiebke
Androgen excess is a key feature of polycystic ovarian syndrome (PCOS). Pre-receptor regulation contributes to this with increased activation of testosterone (T) to 5α-dihydrotesterone (DHT) by 5α-reductase type 1 (SRD5A1), as we have shown previously in PCOS (Lancet 1990,335:431; JCE&M 2003,88:2760). Peripheral blood mononuclear cells (PBMCs) are easily accessible and a useful model for studying pre-receptor regulation in the immune compartment. We have previous...